Event Details

Network Physiology in Liver Failure

This webinar is the fourth and final session of the ‘Network Physiology: Mapping Physiological Networks in Health and Disease’ webinar series. This series also includes webinars on Network Physiology: Overview, Network Physiology in Extreme Environments and Network Physiology in Respiratory Diseases and Critical Care.

Registration opens on Tuesday 21 January 2025.

The liver plays a central role in metabolic and immunological processes, making it a critical hub for the regulation of diverse physiological mechanisms in both health and disease. The functional connectivity between the liver and other organs is well recognized by clinicians, as patients with liver failure often exhibit involvement of multiple organ systems. For instance, chronic liver failure (cirrhosis) is associated with portal hypertension, renal dysfunction, encephalopathy, cardiomyopathy, autonomic dysfunction, impaired immune responses, and disrupted circadian rhythms. Cirrhosis is, therefore, a multi-systemic disease that affects the entire network of organ systems, extending far beyond the liver’s metabolic functions. Treating complications in such a complex disorder is particularly challenging, as inhibiting a pathway in one subsystem can provoke a paradoxical response in another, potentially reducing the chances of adaptation and survival.

A network physiology approach to liver disease and its involvement of extra-hepatic organ systems represents a new frontier with promising research and findings. While organ-specific physiological disruptions have been extensively studied over the past decades, recent works continue to support the need for a holistic, network approach.

In this webinar, we discuss the importance of an integrated approach to understanding the complications of liver failure. We also highlight a novel network techniques, which uses routine clinical and laboratory data to assess physiological network on the individual patient level. Additionally, we showcase findings from three recent studies that demonstrate the utility of physiological network mapping in prognostication and predicting therapeutic responses in liver failure.

Speakers
Professor Sara Montagnese, University of Padova, Italy and University of Surrey, UK
Dr Tope Oyelade, Keele University, UK and University College London, UK

Non members need to create a guest account to register. Registration closes at 23:59 GMT on Monday 31 March 2025.

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